prostate cancer — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7020	Astragenol		Others
	Astragenol is an intermediate for the synthesis of astragenel derivatives. Astragenol derivatives are promising anti-inflammatory drugs in prostate cancer research.		Others
T22263	Bavdegalutamide	ARV-110	Androgen Receptor
	Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...		Androgen Receptor
T8188	Podophyllotoxone		Others , Microtubule Associated
	Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.		Others , Microtubule Associated
T0380	Bicalutamide	ICI-176334	Androgen Receptor , Autophagy
	Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.		Androgen Receptor , Autophagy
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T7690	2-hydroxy Flutamide		Androgen Receptor
	2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer		Androgen Receptor
T60051	VPC-18005		Others
	VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.		Others
TN2097	Pomolic acid		Apoptosis , Caspase , HIV Protease , AMPK
	Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.		Apoptosis , Caspase , HIV Protease , AMPK
T3160	HUHS015		Others
	HUHS015 is a potent PCA-1/ALKBH3 inhibitor.		Others
T8217	Enzalutamide carboxylic acid		Androgen Receptor , Drug Metabolite
	Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .		Androgen Receptor , Drug Metabolite
T9721	ML339		CXCR
	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.		CXCR
T16522	Phenoxodiol	Dehydroequol,Idronoxil,Haginin E	Apoptosis , IAP , Caspase , Topoisomerase , p53
	Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop...		Apoptosis , IAP , Caspase , Topoisomerase , p53
T39695	ARD-2128		Androgen Receptor
	ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...		Androgen Receptor
T1134	Clofoctol		Antibacterial , Antibiotic
	Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.		Antibacterial , Antibiotic
T12928	SK33		Androgen Receptor
	SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.		Androgen Receptor
T25492	Hepln-13	Hepln 13,Hepln13	c-Met/HGFR
	Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.		c-Met/HGFR
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T6889	MI-136		Apoptosis , Epigenetic Reader Domain , Androgen Receptor
	MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.		Apoptosis , Epigenetic Reader Domain , Androgen Receptor
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor